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The impact of profenofos, an organophosphate pesticide on the kidney of Indian freshwater teleost fish Notopterus notopterus was evaluated. The experimental group was exposed to sublethal concentration of profenofos at 7, 14 and 21 days. Histopathological changes due to the toxicity of pesticide in experimental and control kidney of the fish were observed by killing the animal every 7, 14 and 21 days. The kidneys were fixed in Bouin’s solution, dehydrated in graded ethanol, infiltrated in xylene, sectioned at 4-6 µ and stained in haematoxylin and eosin. Haemorrhage, oedema, fragmented glomeruli and elongated kidney tubules in experimental fish, and no effect were however observed in control fishes. It is concluded that profenofos is significantly toxic to the fish.
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