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The therapeutic effects of curcumin and/or dimethyl dimethoxy biphenyl dicarboxylate on rats drinking alcohol were evaluated in the present study. Albino Wister rats drinking 20% ethanol in drinking water were treated with curcumin (100 mg/kg body weight) and /or DDB (50 mg/ kg body weight) mixed in diet for 8 weeks. ALT and AST enzymes were significantly reduced in rat drinking alcohol and treated with DDB or Diferuloylmethane compared with rats drinking alcohol (p<0.05). On the other hand, in case of mixed treatment with curcumin and DDB, AST enzyme was elevated significantly compared with rat drinking alcohol(P<0.05). GGT enzyme was reduced after treatment of alcohol drinking rats with curcumin or DDB in comparing with alcohol drinking rats. MDA concentration in liver homogenate significantly reduced in rats drinking alcohol and treated with DDB compared with rats drinking alcohol (p<0.05). However, serum MDA showed a significant reduction in rats drinking alcohol and treated with curcumin compared with rats drinking alcohol (P<0.05). Histopathological studies revealed liver tissue damage after alcohol administration, however an improvement in liver tissue after treatment with curcumin and DDB. In conclusion, curcumin and DDB can influence and improve the impaired antioxidant defense mechanisms resulted from ethanol and combined treatment with curcumin and DDB has no effects.
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