Asian Journal of Research in Zoology <p style="text-align: justify;"><strong>Asian Journal of Research in&nbsp;Zoology&nbsp;</strong>aims to publish high-quality papers (<a href="/index.php/AJRIZ/general-guideline-for-authors">Click here for Types of paper</a>) in all aspects of Zoology. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.&nbsp;</p> en-US (Asian Journal of Research in Zoology) (Asian Journal of Research in Zoology) Mon, 26 Aug 2019 10:52:02 +0000 OJS 60 Biochemical, Histopathological and Mutagenic Changes Following the Co-administration of Antihelminthic and Antimalarial Drugs in Wistar Rats <p><strong>Aim: </strong>To determine the effects of antimalaria and antheminthic drugs combination in the incidence of histopathological alteration and biochemical modulations in liver and kidney of albino rats.</p> <p><strong>Place and Duration of Study: </strong>The study was undertaken at the Zoology Department University of Lagos Akoka Lagos Nigeria.</p> <p><strong>Methodology: </strong>A total of twenty (25) Male adult albino rats of 13-15 weeks old were divided into 5 groups of 5 rats each and daily oral administration of human therapeutic doses of praziquantel (PZQ 50 mg/kg body weight) separate and in combination with ivermectin (IVM 0.4 mg/kg body weight), albendazole (ALB 15 mg/kg body weight) and Artemether-lumefanthrine (ACT 140 mg/kg body weight) was administered with the&nbsp; group which serve as the control receiving 1ml distilled water. Toxic effects due to these treatments were investigated using histopathological, biochemical and mutagenic indices at day 8<sup>th</sup> and 15<sup>th</sup> of the study.</p> <p><strong>Results: </strong>Biochemical assessment revealed significant reduction in AST, ALT, ALP and potassium in the treatment group compared to the control. Increase in the level calcium, Albumin and bicarbonate were also observed in treatment groups. Histopathological assessment of the liver showed a general incidence of focal inflammation along the portal tract area, but did not show any differential severity across treatment groups except for single PZQ treatment group which were characterized by fatty infiltration. A general occurrence of mesangial damage and glomerula injury was observed in kidney tissues. Renal lesions were more severe in single PZQ + IVM treatment groups while mild lesions characterized renal tissue from PZQ+ACT treatment groups. Mutagenic effects as indicated by the high incidence of sperm head abnormalities was recorded across combination treatments especially in PZQ+ IVR and PZQ+ ACT groups.</p> <p><strong>Conclusion: </strong>Findings suggest that combination therapies are synergistic and could result in nephrotoxicity, antidiuretic effects, dehydration and mutagenicity at human therapeutic doses.</p> A. A. Obiajunwa, E. T. Idowu, O. A. Otubanjo ##submission.copyrightStatement## Mon, 26 Aug 2019 00:00:00 +0000 Mound Distribution and Soil Transformation by Macrotermes bellicosus in Bagudo and Augie in Kebbi State, Nigeria <p>The study was carried out to determine the distribution and soil transformation by <em>Macrotermes bellicosus</em> species. Two local government areas of Kebbi State namely; Bagudo and Augie were selected for the study. Field survey and proximate analysis was used for the study, data generated were analyzed using descriptive (Means) and inferential (ANOVA) statistics. Mounds were manually counted; where distance, height and basal circumferences were measured using measuring tape. Results obtained showed mound size was significantly different (P˂0.05) among the study area. Physical characteristics of mounds such as distance, basal circumference, height: were also significantly different (P˂0.05) in all the locations. Dry land and wet land showed no significant (P˃0.05) difference exhibited in physical characteristics. Results indicated significant (P˂0.05) difference in Cation exchange capacity (C.E.C), sand, silt, and clay, and all mineral elements in study locations. Mound soils differed: (P˂0.05) significantly in Cation exchange capacity (C.E.C), sand, silt, and clay and all the elements in study locations: In conclusion, termites: can be considered to be cheap agents of soil amendments which can help farmers in improving soil fertility.</p> H. A. Shindi, H. M. Bandiya, M. M. Yahaya, A. Aminu ##submission.copyrightStatement## Wed, 11 Sep 2019 00:00:00 +0000 A Survey of Urinary Schistosomiasis among Secondary School Students in Jalingo Town, Jalingo Local Government Area, Taraba State <p>This study was carried out to determine the prevalence of urinary Schistosomiasis among secondary school students in Jalingo town, Jalingo local government area, Nigeria. Ordinary centrifugal sedimentation technique was used and the deposits were examined microscopically. Data collected were analyzed using chi square. Out of the 200 samples examined, 37 (18.5%) had infection, with no significant difference (p&gt;0.05) in infection rates between males (21.1%) and females (15.1%). Among the two schools sampled School A had the highest prevalence (22.0%) followed by School B (15.0%) with no significant difference (p&gt;0.05). Children aged 9-12 years (60.0%) were more infected than those aged 19-21 (13.0%) (p&lt;0.05).There was a close relationship between haematuria and positive urine samples as 72.7% of the students tested positive excreted blood in their urine (p&lt;0.05). Major risk factors were poor hygiene, ignorance and poverty. The results of this study show that secondary school students harbor infection and are a source of transmission of Schistosomiasis in the study area. Planning and provision of drugs for treatment should be considered in disease prevention and control programmes. Community participatory health education should be encouraged as the first step in reducing infection and transmission of the disease.</p> Zakki Yula Hosea, Liamngee Kator, Jacob John Geraji ##submission.copyrightStatement## Mon, 16 Sep 2019 00:00:00 +0000